Single-Cell Profiling Shows Murine Forebrain Neural Stem Cells Reacquire a Developmental State when Activated for Adult Neurogenesis

Summary: The transitions from developing to adult quiescent and activated neural stem cells (NSCs) are not Toys well understood.Here, we use single-cell transcriptional profiling and lineage tracing to characterize these transitions in the murine forebrain.We show that the two forebrain NSC parental populations, embryonic cortex and ganglionic emin

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Multiple CRF01_AE/CRF07_BC Recombinants Enhanced the HIV-1 Epidemic Complexity Among MSM in Shenyang City, Northeast China

The transmission of Unique Recombinant Forms (URFs) has complicated the molecular epidemic of HIV-1.This increasing genetic diversity has implications for prevention surveillance, diagnosis, and vaccine design.In this study, we characterized the HIV-1 URFs from 135 newly diagnosed HIV-1 infected cases between 2016 and 2020 in Shenyang, northeast Ch

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The Phylogeny, Metabolic Potentials, and Environmental Adaptation of an Anaerobe, Abyssisolibacter sp. M8S5, Isolated from Cold Seep Sediments of the South China Sea

Bacillota are widely distributed in various environments, owing to their CHROMA SILK versatile metabolic capabilities and remarkable adaptation strategies.Recent studies reported that Bacillota species were highly enriched in cold seep sediments, but their metabolic capabilities, ecological functions, and adaption mechanisms in the cold seep habita

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